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Clinical Trials is a peer-reviewed journal published by SAGE, covering Statistical Methods in Clinical Trials, Ethics in Clinical Research, Meta-analysis and systematic reviews. Over its lifetime it has published 2,363 papers, which have received 48,323 citations.
| Publisher | SAGE |
|---|---|
| Reference style | Numbered (Vancouver) Numbered — [1], [2] in the text 1. Smith A, Jones B, Lee C. A representative article title. Clinical Trials. 2023;12(3):45–58.
Formats any DOI in Clinical Trials style. No sign-up. |
| Publishes research in | Statistical Methods in Clinical Trials Ethics in Clinical Research Meta-analysis and systematic reviews Advanced Causal Inference Techniques Health Systems, Economic Evaluations, Quality of Life |
| ISSN | 1740-7745 |
| Citation impact (2-yr) | 2.2 |
| h-index | 93 |
| i10-index | 1,007 |
| Top institutions publishing here | Johns Hopkins University |
| Journal website | ctj.sagepub.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Citations each year’s papers have accumulated so far — the most recent years are still building up.
BACKGROUND: The published clinical research literature may be distorted by the pursuit of statistically significant results. PURPOSE: We aimed to develop a test to explore biases stemming from the pursuit of nominal statistical significance. METHODS: The exploratory test evaluates whether there is a relative excess of formally significant findings in the published literature due to…
BACKGROUND: Randomized controlled trials almost always have some individuals with missing outcomes. Inadequate handling of these missing data in the analysis can cause substantial bias in the treatment effect estimates. We examine how missing outcome data are handled in randomized controlled trials in order to assess whether adequate steps have been taken to reduce nonresponse…
BACKGROUND: High blood pressure is an important public health concern because it is highly prevalent and a risk factor for adverse health outcomes, including coronary heart disease, stroke, decompensated heart failure, chronic kidney disease, and decline in cognitive function. Observational studies show a progressive increase in risk associated with blood pressure above 115/75 mm Hg.…
BACKGROUND: The intention-to-treat comparison is the primary, if not the only, analytic approach of many randomized clinical trials. PURPOSE: To review the shortcomings of intention-to-treat analyses, and of 'as treated' and 'per protocol' analyses as commonly implemented, with an emphasis on problems that are especially relevant for comparative effectiveness research. METHODS AND RESULTS: In placebo-controlled…
BACKGROUND: The increasing cost of clinical research has significant implications for public health, as it affects drug companies' willingness to undertake clinical trials, which in turn limits patient access to novel treatments. Thus, gaining a better understanding of the key cost drivers of clinical research in the United States is important. PURPOSE: The study which…
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