Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds in humans. It is, however, important to realise that humans differ from animals with regards to isoform composition, expression and catalytic activities of drug-metabolising enzymes. In this review the authors describe similarities and differences in…
Expert Opinion on Drug Metabolism & Toxicology Template
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About the Expert Opinion on Drug Metabolism & Toxicology format
Expert Opinion on Drug Metabolism & Toxicology is a peer-reviewed journal published by Taylor & Francis, covering Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Pharmacological Effects and Toxicity Studies.
| Publisher | Taylor & Francis |
|---|---|
| Reference style | Author–year (Chicago, T&F) Author–year — (Smith, 2023) in the text Smith, Ada, Ben Jones, and Cara Lee. 2023. "A Representative Article Title." Expert Opinion on Drug Metabolism & Toxicology 12 (3): 45–58.
Formats any DOI in Expert Opinion on Drug Metabolism & Toxicology style. No sign-up. |
| Publishes research in | Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Computational Drug Discovery Methods Drug-Induced Hepatotoxicity and Protection |
| ISSN | 1742-5255 |
| Citation impact (2-yr) | 4.25 |
| h-index | 119 |
| i10-index | 1,647 |
| Total citations | 82,312 |
| Top institutions publishing here | Weatherford College |
| Journal website | www.tandfonline.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in Expert Opinion on Drug Metabolism & Toxicology per year
Citation impact of Expert Opinion on Drug Metabolism & Toxicology by publication year
Citations each year’s papers have accumulated so far — the most recent years are still building up.
Most-cited papers in Expert Opinion on Drug Metabolism & Toxicology
BACKGROUND: Aldehydes are highly reactive molecules. While several non-P450 enzyme systems participate in their metabolism, one of the most important is the aldehyde dehydrogenase (ALDH) superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation. OBJECTIVE: This article presents a review of what is currently known about each member of the human ALDH superfamily including the…
Caco-2 cells are a human colon epithelial cancer cell line used as a model of human intestinal absorption of drugs and other compounds. When cultured as a monolayer, Caco-2 cells differentiate to form tight junctions between cells to serve as a model of paracellular movement of compounds across the monolayer. In addition, Caco-2 cells express…
The Simcyp population-based absorption, distribution, metabolism and excretion simulator is a platform and database for 'bottom-up' mechanistic modelling and simulation of the processes of oral absorption, tissue distribution, metabolism and excretion of drugs and drug candidates in healthy and disease populations. It combines experimental data generated routinely during preclinical drug discovery and development from in…
BACKGROUND: The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic enzymes that are sandwiched between two membrane barriers…