Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
Yu Sun, Wenzhou Liu, Tao Liu et al. · 22 Jun 2015
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this…
Dopamine Receptor Signaling
Kim A. Neve, Jeremy K. Seamans, Heather Trantham‐Davidson · 1 Jan 2004
The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf, which cause sequential…
Thermodynamics of Protein–Ligand Interactions: History, Presence, and Future Aspects
Remo Perozzo, Gerd Folkers, Léonardo Scapozza · 1 Jan 2004
The understanding of molecular recognition processes of small ligands and biological macromolecules requires a complete characterization of the binding energetics and correlation of thermodynamic data with interacting structures involved. A quantitative description of the forces that govern molecular associations requires determination of changes of all thermodynamic parameters, including free energy of binding (deltaG), enthalpy (deltaH),…
Tissue Distribution Profiles of the Human TRPM Cation Channel Family
Elena Fonfría, Paul R. Murdock, Fiona S. Cusdin et al. · 1 Jan 2006
Eight members of the TRP-melastatin (TRPM) subfamily have been identified, whose physiological functions and distribution are poorly characterized. Although tissue expression and distribution patterns have been reported for individual TRPM channels, comparisons between individual studies are not possible because of variations in analysis techniques and tissue selection. We report here a comparative analysis of the…
The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus
Markus H. Heim · 1 Jan 1999
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and growth factors have been found to activate Jaks and STATs. Jaks (Janus Kinases) are a unique class of tyrosine kinases that associate with cytokine receptors. Upon ligand binding, they activate members of…
