Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp) degradation are reviewed. The KP accounts for ~95% of dietary Trp degradation, of which 90% is attributed to the hepatic KP. During immune activation, the minor extrahepatic KP plays a more active role. The KP is rate-limited by its first enzyme, Trp…
International Journal of Tryptophan Research Template
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About the International Journal of Tryptophan Research format
International Journal of Tryptophan Research is a peer-reviewed journal published by SAGE, covering Tryptophan and brain disorders, Stress Responses and Cortisol, Gut microbiota and health.
| Publisher | SAGE |
|---|---|
| Reference style | Author–year (Harvard) Author–year — (Smith, 2023) in the text Smith, A., Jones, B. and Lee, C. (2023) 'A representative article title', International Journal of Tryptophan Research, 12(3), pp. 45–58.
Formats any DOI in International Journal of Tryptophan Research style. No sign-up. |
| Publishes research in | Tryptophan and brain disorders Stress Responses and Cortisol Gut microbiota and health Bipolar Disorder and Treatment Diet and metabolism studies |
| ISSN | 1178-6469 |
| Citation impact (2-yr) | 3.5 |
| h-index | 42 |
| i10-index | 136 |
| Total citations | 8,959 |
| Article processing charge | $750 |
| Open access | Yes |
| Top institutions publishing here | Macquarie University |
| Journal website | journals.sagepub.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in International Journal of Tryptophan Research per year
Citation impact of International Journal of Tryptophan Research by publication year
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Most-cited papers in International Journal of Tryptophan Research
An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan's role in synthesis…
Tryptophan is an essential amino acid that can be metabolised through different pathways, a major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2,3-dioxygenase, is strongly stimulated by inflammatory molecules, particularly interferon gamma. Thus, the kynurenine pathway is often systematically up-regulated when the immune response is activated. The biological significance is that…
Tryptophan is an essential plant-derived amino acid that is needed for the in vivo biosynthesis of proteins. After consumption, it is metabolically transformed to bioactive metabolites, including serotonin, melatonin, kynurenine, and the vitamin niacin (nicotinamide). This brief integrated overview surveys and interprets our current knowledge of the reported multiple analytical methods for free and protein-bound…
Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral (PNS) and central nervous systems (CNS). It is characterised by a dose-relevant spectrum of clinical findings related to the level of free serotonin (5-hydroxytryptamine [5-HT]), or 5-HT receptor activation (predominantly the…