Cytokines play an important role in controlling the homoeostasis of the immune system. Infection with HIV results in dysregulation of the cytokine profile in vivo and in vitro. During the course of HIV-1 infection secretion of T-helper type 1 (Th1) cytokines, such as interleukin (IL)-2, and antiviral interferon (IFN)-gamma, is generally decreased, whereas production of…
Antiviral chemistry & chemotherapy Template
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About the Antiviral chemistry & chemotherapy format
Antiviral chemistry & chemotherapy is a peer-reviewed journal published by SAGE, covering HIV/AIDS drug development and treatment, HIV Research and Treatment, Herpesvirus Infections and Treatments.
| Publisher | SAGE |
|---|---|
| Reference style | Author–year (Harvard) Author–year — (Smith, 2023) in the text Smith, A., Jones, B. and Lee, C. (2023) 'A representative article title', Antiviral chemistry & chemotherapy, 12(3), pp. 45–58.
Formats any DOI in Antiviral chemistry & chemotherapy style. No sign-up. |
| Publishes research in | HIV/AIDS drug development and treatment HIV Research and Treatment Herpesvirus Infections and Treatments Cytomegalovirus and herpesvirus research Biochemical and Molecular Research |
| ISSN | 0956-3202 |
| h-index | 66 |
| i10-index | 603 |
| Total citations | 23,772 |
| Article processing charge | $1,500 |
| Top institutions publishing here | Rega Institute for Medical Research |
| Journal website | www.intmedpress.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in Antiviral chemistry & chemotherapy per year
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Most-cited papers in Antiviral chemistry & chemotherapy
The acyclic nucleoside phosphonate (ANP) analogues are broad-spectrum antiviral agents, with potent and selective antiviral activity in vitro and in vivo. The prototype compounds are: ( S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC, cidofovir), which is active against a wide variety of DNA viruses; 9-(2-phosphonylmethoxyethyl)adenine (PMEA, adefovir), which is active against retro-, herpes- and hepadnaviruses, and ( R)-9-(2-phosphonylmethoxypropyl) adenine (PMPA),…
Several 5-N-alkyl and 5-N,N-dialkylcarbamoyl substituted analogues of the anti-human immunodeficiency virus (HIV) type 1 lead compound [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-5- (N,N-dimethylcarbamoyl)-1,2,3-triazole]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide) have been prepared and evaluated as inhibitors of HIV-1 replication. A new regiospecific synthetic procedure is described. The compounds were prepared by cycloaddition of the appropriate glycosylazide to 2-oxoalkylidentriphenyl-phosphoranes, followed by treatment with primary or secondary…
Eighteen amino acid esters of the antiherpetic drug, acyclovir, were synthesized as potential prodrugs for oral administration. The esters were examined for in vitro antiviral activity against herpes simplex virus Type 1 (HSV-1). They were found to have less potency than the parent compound. Their efficiencies as prodrugs were evaluated in rats by measuring the…
Compounds approved for therapeutic use and in vitro inhibitors of severe acute respiratory syndrome coronavirus (SARS-CoV) were evaluated for inhibition in the mouse SARS-CoV replication model. A hybrid interferon, interferon alpha (IFN-alpha) B/D, and a mismatched double-stranded (ds) RNA interferon (IFN) inducer, Ampligen (poly I:poly C124), were the only compounds that potently inhibited virus titres…