PLOS

PLOS Computational Biology Template

Write in a clean editor, then format for PLOS Computational Biology in one click — DocuGuru applies the official PLOS template with numbered references and exports a submission-ready PDF plus the editable LaTeX source. Free to start.

About the PLOS Computational Biology format

PLOS Computational Biology is a peer-reviewed journal published by PLOS, covering Neural dynamics and brain function, Bioinformatics and Genomic Networks, Gene Regulatory Network Analysis. Over its lifetime it has published 12,902 papers, which have received 683,633 citations.

PublisherPLOS
Reference styleNumbered (Vancouver)
Numbered — [1], [2] in the text
1. Smith A, Jones B, Lee C. A representative article title. PLOS Computational Biology. 2023;12(3):45–58.

Formats any DOI in PLOS Computational Biology style. No sign-up.

Publishes research inNeural dynamics and brain function Bioinformatics and Genomic Networks Gene Regulatory Network Analysis Protein Structure and Dynamics Genomics and Phylogenetic Studies
ISSN1553-734X
Citation impact (2-yr)4.08
h-index288
i10-index8,746
Article processing charge$2,655
Open accessYes — indexed in DOAJ
Top institutions publishing hereCentre National de la Recherche Scientifique
Journal websitejournals.plos.org
You getA submission-ready PDF and the editable LaTeX source — ready to submit.

Papers published in PLOS Computational Biology per year

616
2014
647
2015
608
2016
635
2017
585
2018
710
2019
773
2020
1K
2021
910
2022
721
2023
754
2024
893
2025

Citation impact of PLOS Computational Biology by publication year

53K
2014
47.4K
2015
38.3K
2016
51.2K
2017
33.2K
2018
34.8K
2019
28.2K
2020
30.3K
2021
18.9K
2022
10.1K
2023
6.1K
2024
2.1K
2025

Citations each year’s papers have accumulated so far — the most recent years are still building up.

Most-cited papers in PLOS Computational Biology

Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads

Ryan R. Wick, Louise M. Judd, Claire L. Gorrie et al. · 8 Jun 2017

The Illumina DNA sequencing platform generates accurate but short reads, which can be used to produce accurate but fragmented genome assemblies. Pacific Biosciences and Oxford Nanopore Technologies DNA sequencing platforms generate long reads that can produce complete genome assemblies, but the sequencing is more expensive and error-prone. There is significant interest in combining data from…

8,888 citations Cite SaveGo to paper →
Accelerated Profile HMM Searches

Sean R. Eddy · 20 Oct 2011

Profile hidden Markov models (profile HMMs) and probabilistic inference methods have made important contributions to the theory of sequence database homology search. However, practical use of profile HMM methods has been hindered by the computational expense of existing software implementations. Here I describe an acceleration heuristic for profile HMMs, the "multiple segment Viterbi" (MSV) algorithm.…

7,581 citations Cite SaveGo to paper →
BEAST 2: A Software Platform for Bayesian Evolutionary Analysis

Remco Bouckaert, Joseph Heled, Denise Kühnert et al. · 10 Apr 2014

We present a new open source, extensible and flexible software platform for Bayesian evolutionary analysis called BEAST 2. This software platform is a re-design of the popular BEAST 1 platform to correct structural deficiencies that became evident as the BEAST 1 software evolved. Key among those deficiencies was the lack of post-deployment extensibility. BEAST 2…

7,036 citations Cite SaveGo to paper →
Software for Computing and Annotating Genomic Ranges

Michael Lawrence, Wolfgang Huber, Hervé Pagès et al. · 8 Aug 2013

We describe Bioconductor infrastructure for representing and computing on annotated genomic ranges and integrating genomic data with the statistical computing features of R and its extensions. At the core of the infrastructure are three packages: IRanges, GenomicRanges, and GenomicFeatures. These packages provide scalable data structures for representing annotated ranges on the genome, with special support…

5,064 citations Cite SaveGo to paper →
BEAST 2.5: An advanced software platform for Bayesian evolutionary analysis

Remco Bouckaert, Timothy G. Vaughan, Joëlle Barido‐Sottani et al. · 8 Apr 2019

Elaboration of Bayesian phylogenetic inference methods has continued at pace in recent years with major new advances in nearly all aspects of the joint modelling of evolutionary data. It is increasingly appreciated that some evolutionary questions can only be adequately answered by combining evidence from multiple independent sources of data, including genome sequences, sampling dates,…

4,783 citations Cite SaveGo to paper →

PLOS Computational Biology template — frequently asked questions

How do I write a paper in the PLOS Computational Biology format?
In DocuGuru you write your manuscript in a normal editor — no LaTeX setup required — and select the PLOS Computational Biology template. When you export, DocuGuru compiles the paper into the official PLOS format and hands you a submission-ready PDF along with the editable LaTeX source.
What reference style does PLOS Computational Biology use?
PLOS Computational Biology uses Numbered (Vancouver) references, shown as numbered [1], [2] markers in the text. DocuGuru formats every in-text citation and the reference list in this exact style automatically. A reference appears like this: 1. Smith A, Jones B, Lee C. A representative article title. PLOS Computational Biology. 2023;12(3):45–58.
Do I need to know LaTeX to submit to PLOS Computational Biology?
No. DocuGuru generates the article LaTeX class and compiles the PDF for you in the background, so you get a PLOS-ready PLOS Computational Biology document without writing any LaTeX. If you do want it, the LaTeX source is included in the export.
Can I import an existing draft into the PLOS Computational Biology template?
Yes. Paste or upload your current manuscript — Word, LaTeX, Markdown, or plain text — and DocuGuru reflows it into the PLOS Computational Biology format with correct headings, figures, tables, and numbered citations.
What is PLOS Computational Biology?
PLOS Computational Biology features works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is a life sciences and medicine journal, published by PLOS.
Can I export a submission-ready PLOS Computational Biology PDF?
Yes — DocuGuru produces a PDF built with the official PLOS Computational Biology template (the article class) that is ready to submit to PLOS, together with the matching LaTeX source files.
How much does the PLOS Computational Biology template cost?
You can start writing in the PLOS Computational Biology template for free. Exporting the final submission-ready PLOS Computational Biology PDF and LaTeX source is part of DocuGuru's paid plans — see the app for current pricing.
Use the PLOS Computational Biology template