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Current Protocols in Toxicology is a peer-reviewed journal published by Wiley, covering Animal testing and alternatives, Carcinogens and Genotoxicity Assessment, Sulfur Compounds in Biology.
| Publisher | Wiley |
|---|---|
| Reference style | Author–year (Chicago) Author–year — (Smith, 2023) in the text Smith, Ada, Ben Jones, and Cara Lee. 2023. "A Representative Article Title." Current Protocols in Toxicology 12 (3): 45–58.
Formats any DOI in Current Protocols in Toxicology style. No sign-up. |
| Publishes research in | Animal testing and alternatives Carcinogens and Genotoxicity Assessment Sulfur Compounds in Biology Immunotoxicology and immune responses Mitochondrial Function and Pathology |
| ISSN | 1934-9254 |
| h-index | 45 |
| i10-index | 184 |
| Total citations | 7,729 |
| Article processing charge | $5,050 |
| Top institutions publishing here | University of Washington |
| Journal website | currentprotocols.onlinelibrary.wiley.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Citations each year’s papers have accumulated so far — the most recent years are still building up.
Abstract Drug discovery heavily relies on cell viability studies to assess the potential toxicity of drug candidates. L ‐Lactate dehydrogenase (LDH) is a cytoplasmic enzyme that catalyzes the concomitant interconversions of pyruvate to L ‐lactate and NADH to NAD + during glycolysis, and the reverse reactions during the Cori cycle. In response to cellular damage,…
The Caco-2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in vivo absorption data for many drugs and chemicals. As a consequence,…
The thioredoxin system is ubiquitous, providing reducing equivalents to essential biosynthetic enzymes like ribonucleotide reductase. It is essential for cellular redox regulation, control of oxidative stress, and protection against oxidative damage. This unit includes protocols for measuring thioredoxin or thioredoxin reductase in biological preparations or as purified enzymes.
There is currently considerable interest in what is termed "oxidative stress," or the oxidation of biological macromolecules, with emphasis on its involvement in various diseases and toxicities and methods to limit either its occurrence or effects. This unit describes traditional methods to measure the extent or rate of lipid peroxidations, including assays for conjugated dienes,…
Heme (iron protoporphyrin IX) is a prosthetic group for a number of hemoproteins in different tissues (e.g., hemoglobin, myoglobin, cytochrome P-450s, mitochondrial cytochromes, catalases, and peroxidases). Mutations in the biosynthetic pathway can affect the synthesis and/or degradation of heme. Several assays are provided in this unit for quantifying heme: a spectrophotometric assay based on the…
