The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors. It enhances, therefore, the release of norepinephrine and 5-HT1A-mediated serotonergic transmission. This dual mode of action may conceivably…
CNS Drug Reviews Template
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About the CNS Drug Reviews format
CNS Drug Reviews is a peer-reviewed journal published by Wiley, covering Neuroscience and Neuropharmacology Research, Receptor Mechanisms and Signaling, Cholinesterase and Neurodegenerative Diseases.
| Publisher | Wiley |
|---|---|
| Reference style | Author–year (Chicago) Author–year — (Smith, 2023) in the text Smith, Ada, Ben Jones, and Cara Lee. 2023. "A Representative Article Title." CNS Drug Reviews 12 (3): 45–58.
Formats any DOI in CNS Drug Reviews style. No sign-up. |
| Publishes research in | Neuroscience and Neuropharmacology Research Receptor Mechanisms and Signaling Cholinesterase and Neurodegenerative Diseases Neurotransmitter Receptor Influence on Behavior Nicotinic Acetylcholine Receptors Study |
| ISSN | 1080-563X |
| h-index | 69 |
| i10-index | 202 |
| Total citations | 16,861 |
| Top institutions publishing here | Yale University |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in CNS Drug Reviews per year
Citation impact of CNS Drug Reviews by publication year
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Most-cited papers in CNS Drug Reviews
Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It occupies a unique position among analgesic drugs. Unlike NSAIDs it is almost unanimously considered to have no antiinflammatory activity and does not produce gastrointestinal damage or untoward cardiorenal effects. Unlike opiates it is almost ineffective…
In the present article, we review the pharmacological properties of KDS-4103 (URB597), a highly potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (FAAH), which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide. In vitro, KDS-4103 inhibits FAAH activity with median inhibitory concentrations (IC(50)) of 5 nM in rat brain membranes and 3 nM…
Memantine has been demonstrated to be safe and effective in the symptomatic treatment of Alzheimer's disease (AD). While the neurobiological basis for the therapeutic activity of memantine is not fully understood, the drug is not a cholinesterase inhibitor and, therefore, acts differently from current AD therapies. Memantine can interact with a variety of ligand-gated ion…
Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) with currently approved indications for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. It is also used in the treatment of generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache. Paroxetine, a phenylpiperidine derivative, is the most potent…