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npj Systems Biology and Applications is a peer-reviewed journal published by Springer Nature, covering Gene Regulatory Network Analysis, Bioinformatics and Genomic Networks, Microbial Metabolic Engineering and Bioproduction. Over its lifetime it has published 800 papers, which have received 13,159 citations.
| Publisher | Springer Nature |
|---|---|
| Reference style | Superscript numbered (Nature) Superscript — small raised numerals in the text 1. Smith, A., Jones, B. & Lee, C. A representative article title. npj Systems Biology and Applications 12, 45–58 (2023).
Formats any DOI in npj Systems Biology and Applications style. No sign-up. |
| Publishes research in | Gene Regulatory Network Analysis Bioinformatics and Genomic Networks Microbial Metabolic Engineering and Bioproduction Single-cell and spatial transcriptomics Computational Drug Discovery Methods |
| ISSN | 2056-7189 |
| Citation impact (2-yr) | 4.27 |
| h-index | 56 |
| i10-index | 321 |
| Article processing charge | $2,990 |
| Open access | Yes — indexed in DOAJ |
| Top institutions publishing here | Centre National de la Recherche Scientifique |
| Journal website | www.nature.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Citations each year’s papers have accumulated so far — the most recent years are still building up.
The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic and extrinsic benchmarking schemes, we demonstrate that processing the L1000 data with the characteristic direction (CD) method significantly improves signal to noise compared with the…
New synthetic biology capabilities hold the promise of dramatically improving our ability to engineer biological systems. However, a fundamental hurdle in realizing this potential is our inability to accurately predict biological behavior after modifying the corresponding genotype. Kinetic models have traditionally been used to predict pathway dynamics in bioengineered systems, but they take significant time…
The combination of synthetic and systems biology is a powerful framework to study fundamental questions in biology and produce chemicals of immediate practical application such as biofuels, polymers, or therapeutics. However, we cannot yet engineer biological systems as easily and precisely as we engineer physical systems. In this review, we describe the path from the…
Yarrowia lipolytica is a promising microbial cell factory for the production of lipids to be used as fuels and chemicals, but there are few studies on regulation of its metabolism. Here we performed the first integrated data analysis of Y. lipolytica grown in carbon and nitrogen limited chemostat cultures. We first reconstructed a genome-scale metabolic…
While gene expression profiling is commonly used to gain an overview of cellular processes, the identification of upstream processes that drive expression changes remains a challenge. To address this issue, we introduce CARNIVAL, a causal network contextualization tool which derives network architectures from gene expression footprints. CARNIVAL (CAusal Reasoning pipeline for Network identification using Integer…
