A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method [Sanger, F. & Coulson, A. R. (1975) J. Mol. Biol. 94, 441-448] but makes use of the 2',3'-dideoxy and arabinonucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.…
Proceedings of the National Academy of Sciences Template
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About the Proceedings of the National Academy of Sciences format
Proceedings of the National Academy of Sciences is a peer-reviewed journal published by PNAS, covering RNA and protein synthesis mechanisms, Bacterial Genetics and Biotechnology, Neuroscience and Neuropharmacology Research.
| Publisher | PNAS |
|---|---|
| Reference style | Numbered (PNAS) Numbered — [1], [2] in the text 1. A. Smith, B. Jones, C. Lee, A representative article title. Proceedings of the National Academy of Sciences 12, 45–58 (2023).
Formats any DOI in Proceedings of the National Academy of Sciences style. No sign-up. |
| Publishes research in | RNA and protein synthesis mechanisms Bacterial Genetics and Biotechnology Neuroscience and Neuropharmacology Research Monoclonal and Polyclonal Antibodies Research RNA Research and Splicing |
| ISSN | 0027-8424 |
| Citation impact (2-yr) | 8.05 |
| h-index | 1173 |
| i10-index | 144,911 |
| Total citations | 22,890,303 |
| Top institutions publishing here | Harvard University |
| Journal website | www.pnas.org |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in Proceedings of the National Academy of Sciences per year
Citation impact of Proceedings of the National Academy of Sciences by publication year
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Most-cited papers in Proceedings of the National Academy of Sciences
Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method called Gene Set Enrichment Analysis (GSEA) for interpreting gene expression data. The method derives its power by focusing on gene sets, that is, groups of…
A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. The method results in quantitative transfer of ribosomal proteins from gels containing urea. For sodium dodecyl sulfate gels, the original band pattern was obtained with no loss of resolution, but the transfer was not quantitative. The method allows…
Computational properties of use of biological organisms or to the construction of computers can emerge as collective properties of systems having a large number of simple equivalent components (or neurons). The physical meaning of content-addressable memory is described by an appropriate phase space flow of the state of a system. A model of such a…
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression. The output is displayed graphically, conveying the clustering and the underlying expression data simultaneously in a form intuitive for biologists. We have found in…