Shotgun proteomic methods involving isobaric tagging of peptides enable high-throughput proteomic analysis. iTRAQ reagents allow simultaneous identification and quantitation of proteins in four different samples using tandem mass spectrometry (MS). In this article, we provide a brief description of proteome analysis using iTRAQ reagents and review the current applications of these reagents in proteomic studies.…
Briefings in Functional Genomics and Proteomics Template
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About the Briefings in Functional Genomics and Proteomics format
Briefings in Functional Genomics and Proteomics is a peer-reviewed journal published by Oxford University Press, covering Advanced Proteomics Techniques and Applications, RNA and protein synthesis mechanisms, Genomics and Chromatin Dynamics.
| Publisher | Oxford University Press |
|---|---|
| Reference style | Author–year (OUP) Author–year — (Smith, 2023) in the text Smith, A., Jones, B. and Lee, C. (2023) 'A representative article title', Briefings in Functional Genomics and Proteomics, 12(3), pp. 45–58.
Formats any DOI in the closest standard style — Briefings in Functional Genomics and Proteomics has no published style definition, so this is an approximation. No sign-up. |
| Publishes research in | Advanced Proteomics Techniques and Applications RNA and protein synthesis mechanisms Genomics and Chromatin Dynamics Mass Spectrometry Techniques and Applications Gene expression and cancer classification |
| ISSN | 1473-9550 |
| h-index | 68 |
| i10-index | 246 |
| Total citations | 14,143 |
| Top institutions publishing here | Wellcome Sanger Institute |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
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Most-cited papers in Briefings in Functional Genomics and Proteomics
Several recent studies from the field of epigenetics have combined chromatin-immunoprecipitation (ChIP) with next-generation high-throughput sequencing technologies to describe the locations of histone post-translational modifications (PTM) and DNA methylation genome-wide. While these reports begin to quench the chromatin biologists thirst for visualizing where in the genome epigenetic marks are placed, they also illustrate several advantages…
Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells. This review focuses on the role of enzymes involved…
Data from whole genome association studies can now be used for dual purposes, genotyping and copy number detection. In this review we discuss some of the methods for using SNP data to detect copy number events. We examine a number of algorithms designed to detect copy number changes through the use of signal-intensity data and…
This review summarizes the essential characteristics of matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS), especially as they relate to its applications in quantitative analysis. Approaches to quantification by MALDI-TOF MS are presented and published applications are critically reviewed.