In an attempt to treat cancer patients with ERBB2 overexpressing tumors, we developed a chimeric antigen receptor (CAR) based on the widely used humanized monoclonal antibody (mAb) Trastuzumab (Herceptin). An optimized CAR vector containing CD28, 4-1BB, and CD3zeta signaling moieties was assembled in a gamma-retroviral vector and used to transduce autologous peripheral blood lymphocytes (PBLs)…
Molecular Therapy Template
Write in a clean editor, then format for Molecular Therapy in one click — DocuGuru applies the official Elsevier template with numbered references and exports a submission-ready PDF plus the editable LaTeX source. Free to start.
About the Molecular Therapy format
Molecular Therapy is a peer-reviewed journal published by Elsevier, covering Virus-based gene therapy research, RNA Interference and Gene Delivery, CRISPR and Genetic Engineering.
| Publisher | Elsevier |
|---|---|
| Reference style | Numbered (Elsevier) Numbered — [1], [2] in the text [1] A. Smith, B. Jones, C. Lee, A representative article title, Molecular Therapy 12 (2023) 45–58.
Formats any DOI in Molecular Therapy style. No sign-up. |
| Publishes research in | Virus-based gene therapy research RNA Interference and Gene Delivery CRISPR and Genetic Engineering Viral Infectious Diseases and Gene Expression in Insects CAR-T cell therapy research |
| ISSN | 1525-0016 |
| Citation impact (2-yr) | 6.51 |
| h-index | 259 |
| i10-index | 5,511 |
| Total citations | 469,783 |
| Article processing charge | $3,900 |
| Top institutions publishing here | University of Pennsylvania |
| Journal website | www.journals.elsevier.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Papers published in Molecular Therapy per year
Citation impact of Molecular Therapy by publication year
Citations each year’s papers have accumulated so far — the most recent years are still building up.
Most-cited papers in Molecular Therapy
In vitro–transcribed mRNAs encoding physiologically important proteins have considerable potential for therapeutic applications. However, in its present form, mRNA is unfeasible for clinical use because of its labile and immunogenic nature. Here, we investigated whether incorporation of naturally modified nucleotides into transcripts would confer enhanced biological properties to mRNA. We found that mRNAs containing pseudouridines…
Despite the therapeutic potential of nucleic acid drugs, their clinical application has been limited in part by a lack of appropriate delivery systems. Exosomes or microvesicles are small endosomally derived vesicles that are secreted by a variety of cell types and tissues. Here, we show that exosomes can efficiently deliver microRNA (miRNA) to epidermal growth…
This study examines transgene expression and biodistribution of adeno-associated virus (AAV) pseudotyped 1–9 after tail vein (TV) injection in male mice. Using a cytomegalovirus (CMV)-luciferase transgene, the time-course of expression in each animal was tracked throughout the experiment. The animals were imaged at 7, 14, 29, 56, and 100 days after the TV injection. The…