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Molecular Therapy — Methods & Clinical Development is a peer-reviewed journal published by Elsevier, covering Virus-based gene therapy research, CRISPR and Genetic Engineering, CAR-T cell therapy research.
| Publisher | Elsevier |
|---|---|
| Reference style | Numbered (Elsevier) Numbered — [1], [2] in the text [1] A. Smith, B. Jones, C. Lee, A representative article title, Molecular Therapy — Methods & Clinical Development 12 (2023) 45–58.
Formats any DOI in Molecular Therapy — Methods & Clinical Development style. No sign-up. |
| Publishes research in | Virus-based gene therapy research CRISPR and Genetic Engineering CAR-T cell therapy research RNA Interference and Gene Delivery Viral Infectious Diseases and Gene Expression in Insects |
| ISSN | 2329-0501 |
| Citation impact (2-yr) | 5.81 |
| h-index | 92 |
| i10-index | 1,174 |
| Total citations | 49,404 |
| Article processing charge | $3,200 |
| Open access | Yes |
| Top institutions publishing here | Inserm |
| Journal website | www.journals.elsevier.com |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Citations each year’s papers have accumulated so far — the most recent years are still building up.
applications, and present key achievements and emerging issues in the field. We will use the liver as a model target tissue for gene transfer based on the large amount of data available from preclinical and clinical studies.
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell malignancies, and chimeric antigen receptor T cell therapy is now being investigated in several hematologic and solid tumor types. Chimeric antigen receptor T cells are generated by removing T cells from a patient’s blood and engineering the cells…
T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers. Since the first clinical reports of their efficacy emerged 7 years ago, investigators have focused on the mechanisms and properties that make CARs effective or toxic, and their…
It has been reported that angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are the main cell entry proteins for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and play a critical role in causing coronavirus disease 2019 (COVID-19). To investigate the expression level of these SARS-CoV-2 host cell entry genes in the lung…
Lentiviral vectors (LV) have seen considerably increase in use as gene therapy vectors for the treatment of acquired and inherited diseases. This review presents the state of the art of the production of these vectors with particular emphasis on their large-scale production for clinical purposes. In contrast to oncoretroviral vectors, which are produced using stable…
