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Science s STKE is a peer-reviewed journal published by AAAS (Science), covering Neuroscience and Neuropharmacology Research, Protein Kinase Regulation and GTPase Signaling, Receptor Mechanisms and Signaling.
| Publisher | AAAS (Science) |
|---|---|
| Reference style | Superscript numbered (Science) Superscript — small raised numerals in the text 1. A. Smith, B. Jones, C. Lee, A representative article title. Science s STKE 12, 45–58 (2023).
Formats any DOI in Science s STKE style. No sign-up. |
| Publishes research in | Neuroscience and Neuropharmacology Research Protein Kinase Regulation and GTPase Signaling Receptor Mechanisms and Signaling Ion channel regulation and function Cellular transport and secretion |
| ISSN | 1525-8882 |
| h-index | 113 |
| i10-index | 572 |
| Total citations | 52,397 |
| Top institutions publishing here | Office of Science |
| Journal website | stke.sciencemag.org |
| You get | A submission-ready PDF and the editable LaTeX source — ready to submit. |
Citations each year’s papers have accumulated so far — the most recent years are still building up.
Members of the nuclear factor kappa B (NF-kappaB) family of dimeric transcription factors (TFs) regulate expression of a large number of genes involved in immune responses, inflammation, cell survival, and cancer. NF-kappaB TFs are rapidly activated in response to various stimuli, including cytokines, infectious agents, and radiation-induced DNA double-strand breaks. In nonstimulated cells, some NF-kappaB…
The hypoxia-inducible factor 1 (HIF-1) was initially identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue. Subsequently, a family of oxygen-dependent protein hydroxylases was found to regulate the abundance and activity of three oxygen-sensitive HIFalpha subunits, which, as part of the HIF heterodimer,…
The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation channels that bear structural similarities to Drosophila TRP. TRP channels play important roles in nonexcitable cells; however, an emerging theme is that many TRP-related proteins are expressed predominantly in the nervous system and function in sensory physiology. The TRP superfamily is…
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1alpha and HIF-1beta subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type-specific manner. The HIF-1alpha subunit is regulated by O2-dependent hydroxylation of proline residue 402, 564,…
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at least 35 related human proteins. Using a somewhat broader definition of sequence similarity reveals a more extended superfamily of more than 170 RAS-related proteins. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be…
